|Base of Operations||Genosha Island Prison|
|Eyes||Brown (Yellow as Lizard)|
|Hair||Brown (Bald as Lizard)|
|Skin||Caucasian (Leather as Lizard)|
|Place of Birth||Louisiana|
|Created by||Artemis Panther|
- I'll recreate the experiments. I'll do whatever is necessary. You mark my words Gyrich, I will be the Lizard once again and I will bite your head off!
Curtis Connors had grown mad with regrowing his arm using lizard DNA. He even completely shut out his own wife and son when they attempted to interact with him. Eventually, he believed he had mastered it, but when he downed the serum, it transformed him into a lizard creature with a savage mind. When he attempted to comprehend what was happening, his wife and son tried to calm down the beast, but he lashed out and murdered them both. He then proceeded to venture into the bayou to wreak havoc.
The Defenders Intervene
Eventually, one of his victims managed to survive and call the police, who were unable to do anything to him, so the Defenders were called. Within a matter of minutes Iron Man, Human Torch, and Captain America arrived. At first, Iron Man scouted the bayou, attempting to pinpoint the Lizard's location, but he managed to yank him down into the swamp before he could pick up a trace. Human Torch then flew in after Iron Man, and attacked the Lizard, burning his raw hide and greatly harming him, enough for Iron Man to get free. Torch told Iron Man to find a cure to the lizard serum, and he would keep the beast busy.
Iron Man and Captain America quickly got to work re-engineering the Lizard serum to create a cure. When Human Torch chased Lizard onto land, he began slowing down because of the cold air, but Human Torch's fire attacks managed to keep him at the same pace, but still harmed him. Eventually, when Lizard ripped off one of Torch's arms, Cap crapped one of the vials and told Tony to keep working if his plan failed. Cap ran out and distracted the Lizard before jumping onto his back and shoving the vial down his throat, which began changing him. Within a few second, he was back to the insane Curtis Connors, and one blow to the face from Captain America knocked him out cold.